Research & Knowledge Resources

This review highlights the potential of mesenchymal and neural stem cells for treating neurodegenerative brain disorders by promoting repair, reducing inflammation, and replacing lost neurons. While early results are promising, challenges remain with cell delivery, variability, and standardization. Further research is needed to safely and effectively translate these therapies to the clinic.

This review highlights the potential of peptide therapies to treat Autism Spectrum Disorder (ASD) by targeting core issues like neuroinflammation, mitochondrial dysfunction, and synaptic imbalance. Peptides such as oxytocin and mitochondria-derived peptides show promise in improving social behavior, reducing inflammation, and restoring cellular function in ASD.

GATC Health is revolutionizing drug development with AI-driven, multiomic technology that reduces costs, shortens timelines, and minimizes animal testing. By simulating human biology and predicting outcomes with high accuracy, their platform accelerates discovery, enhances precision medicine, and promotes a capital-efficient, ethical future for pharmaceutical innovation.

This paper presents a comprehensive review of stem cell therapy in regenerative medicine, comparing allogeneic (donor-derived) and autologous (patient-derived) approaches. It examines induced pluripotent stem cells (iPSCs), which can differentiate into any cell type but carry tumorigenicity risks, and mesenchymal stem cells (MSCs), which have more limited differentiation potential but offer immunomodulatory benefits. The authors analyze the therapeutic applications for conditions like diabetes, neurodegenerative diseases, and cardiovascular disorders, along with the benefits and risks of differentiated versus undifferentiated cells. The review highlights challenges including immune rejection, tumor formation, and improper tissue integration, while discussing future advancements in gene editing and encapsulation technologies to enhance treatment safety and efficacy.

This mini-review explores the potential role of short peptides, specifically Nano-organo Peptides (NOP) and Mito-organo Peptides (MOP), in enhancing longevity and mitigating age-related decline. These peptides influence key physiological functions, including mitochondrial function, proteostasis, cellular senescence, immunogenicity, and metabolic regulation. Emerging research suggests their application in regenerative medicine and aging therapeutics.

This comprehensive review explores the integration of multiple omics approaches (genomics, transcriptomics, proteomics, metabolomics) in drug discovery, discussing key experimental design considerations, challenges in data integration, and emerging computational solutions for analyzing complex molecular datasets to enhance drug development efficiency.

GATC demonstrates alignment with FDA as it considers the use of artificial intelligence to support regulatory decision-making for drug and biological products.

This review examines the potential of autologous bone marrow-derived mononuclear cell transplantation for treating diabetes, exploring its safety and efficacy compared to traditional treatments. The paper analyzes clinical data on using differentiated stem cells for both Type 1 and Type 2 diabetes patients.

The paper explores innovative AI-based approaches to PTSD treatment using GATC Health's Multiomics Advanced Technology (MAT) platform. The research combines genomics, machine learning, and deep learning to identify biomarkers and develop targeted therapeutics, offering a breakthrough in personalized PTSD treatment and prevention strategies for affected populations, particularly military veterans.

The paper examines how machine learning and AI technologies are transforming preclinical drug discovery, highlighting GATC Health's phenotypic drug discovery pipeline that combines deep learning with systems biology approaches to improve drug development efficiency.